Mono Red Madness races you with Fiery Temper cast for its cheap {R} madness cost and Kessig Flamebreather/Guttersnipe triggers, so life total matters enormously; Weather the Storm's lifegain (copied per spell already cast that turn) helps offset the burn. Hydroblast can counter or destroy Lightning Bolt, Fiery Temper, or a resolved Guttersnipe/Kessig Flamebreather. Note that Relic of Progenitus and other graveyard hate do nothing here since madness cards are discarded to exile, not the graveyard, so don't rely on that plan. Trim Campfire and Unfathomable Truths for more immediate interaction, and prioritize Skred and Lightning Bolt on their damage-trigger creatures.

Mono-Blue Terror lives and dies on graveyard density from Thought Scour and Mental Note to cheapen Tolarian Terror and Cryptic Serpent, so Relic of Progenitus is excellent here — exiling their graveyard denies the cost reduction and can strand a Terror in hand. Pyroblast can counter or destroy their blue spells and permanents, including a resolved Delver of Secrets or Tolarian Terror itself. Note Tolarian Terror has Ward {2}, so be ready to pay the tax when targeting it. Cut clunky cards like Pulse of Murasa and Campfire that don't affect the graveyard-fueled game plan, and hold up Counterspell and Dispel to protect your own threats from their permission suite.

Tron's entire plan hinges on assembling Urza's Tower, Urza's Mine, and Urza's Power Plant for a massive mana surplus, and Pillage can destroy any one of those lands (or their own Bonder's Ornament, Expedition Map, and Candy Trail artifacts) to disrupt the engine before it comes online. Relic of Progenitus can exile their graveyard to blank a Relic of Progenitus of their own or deny incidental value, and doubles as a proactive artifact if left uncracked. Cut your own Bonder's Ornament and Campfire, which are too slow in a matchup about denying their ramp, along with Pulse of Murasa and Lose Focus. Save Counterspell for their bombs like Maelstrom Colossus or Pinnacle Kill-Ship rather than their ramp pieces when possible.