Replenish lives and dies by resolving Opalescence with Parallax Wave or Decree of Silence, so Naturalize and Tranquil Domain give you cheap, proactive answers to blow up their enchantments before or after Replenish hits. Tranquil Domain is especially strong since it wipes every non-Aura enchantment at once, undoing a full Replenish in one card. Cut the slow or situational creatures like Anger, Squee, and Yavimaya Granger that don't advance your plan against a combo deck, along with one copy each of Masticore and Skyshroud Poacher since they're too clunky when you need to be proactive. Keep your Natural Order and Survival of the Fittest engine intact to pressure them before they assemble the lock.

Naturalize can destroy a Phyrexian Dreadnought before it attacks, which is one of the few clean mainboard-compatible answers to their turn-one 12/12. Their deck has no enchantments or relevant artifacts beyond the Dreadnought itself, so this is a narrow but important swap rather than a wholesale plan change. Anger, Squee, and Masticore are low-impact against a deck racing to kill you in two swings, so trim them for the extra interaction. Keep developing your mana as fast as possible since beating them often comes down to assembling lethal before the Dreadnought connects twice.

Caller of the Claw is excellent here, flashing in as a surprise blocker and generating a Bear army if their Mogg Fanatic, Goblin Sharpshooter, or combat has already killed creatures that turn, helping you stabilize against their wide board. Wall of Roots gives you a sturdy early blocker against their aggressive Goblin swarm while still ramping your mana. Anger and Squee are mirror-breakers that do little when the opponent is the aggressor, and trimming two Multani's Acolyte reduces fragile echo creatures that die easily to their removal and combat tricks. Keep your core mana engine and Natural Order targets to out-value their go-wide strategy once the board stabilizes.